REFERRED PUBLICATIONS

R. R. Alfano, D. Tata, J. Cordero, P. Tomashefsky, F. W. Longo, and M. A. Alfano, "Laser induced fluorescence spectroscopy from native cancerous and normal tissues," IEEE J Quantum Electron, 20, pp. 1507-1511, 1984.

D. B. Tata, M. Foresti, J. Cordero, P. Tomashefsky, M. A. Alfano, and R. R. Alfano, "Fluorescence polarization spectroscopy and time-resolved fluorescence kinetics of native cancerous and normal rat kidney tissues," Biophys J, 50, pp. 463-469., 1986.

R. R. Alfano, G. Tang, A. Pradham, W. Lam, D. S. J. Choy, and E. Opher, "Fluorescence spectra from cancerous and normal human breast and lung tissues," IEEE Journal of Quantum Electronics, QE-23, pp. 1806-1811, 1987.

R. R. Alfano, A. Pradhan, G. C. Tang, and S. J. Wahl, "Optical spectroscopic diagnosis of cancer and normal breast tissues," Journal of the Optical Society of America B (Optical Physics), 6,, pp. 1015-1023, 1989.

G. C. Tang, A. Pradhan, and R. R. Alfano, "Spectroscopic differences between human cancer and normal lung and breast tissues," Lasers Surg Med, 9, pp. 290-295, 1989.

C. H. Liu, G. C. Tang, A. Pradhan, W. L. Sha, and R. R. Alfano, "Effects of self-absorption by hemoglobins on the fluorescence spectra from normal and cancerous tissues," Lasers in the Life Sciences, 3,, pp. 167-176, 1990.

R. R. Alfano, B. B. Das, J. Cleary, R. Prudente, and E. J. Celmer, "Light sheds light on cancer - distinguishing malignant tumors from benign tissues and tumors," Bulletin of the New York Academy of Medicine, 67, pp. 143-150, 1991.

W. S. Glassman, C. H. Liu, G. C. Tang, S. Lubicz, and R. R. Alfano, "Ultraviolet excited fluorescence spectra from non-malignant and malignant tissues of the gynecological tract," Lasers in the Life Sciences, 5,, pp. 49-58, 1992.

A. Pradhan, B. B. Das, K. M. Yoo, J. Cleary, R. Prudente, E. Celmer, and R. R. Alfano, "Time-resolved UV photoexcited fluorescence kinetics from malignant and non-malignant human breast tissues," Lasers in the Life Sciences, 4,, pp. 225-234, 1992.

S. P. Schantz and R. R. Alfano, "Tissue autofluorescence as an intermediate endpoint in cancer chemoprevention trials," J Cell Biochem Suppl, pp. 199-204, 1993.

R. Glasgold, M. Glasgold, H. Savage, J. Pinto, R. Alfano, and S. Schantz, "Tissue autofluorescence as an intermediate endpoint in NMBA-induced esophageal carcinogenesis," Cancer Letters, 82, pp. 33-41., 1994.

W. Glassman, C.-H. Liu, S. Lubicz, and R. R. Alfano, "Excitation spectroscopy of malignant and non-malignant gynecological tissues," Lasers in the Life Sciences, 6, pp. 99-106, 1994.

W. S. Glassman, M. Steinberg, and R. R. Alfano, "Time resolved and steady state fluorescence spectroscopy from normal and malignant cultured human breast cell lines," Lasers in the Life Sciences, 6, pp. 91-98, 1994.

M. B. Silberberg, H. E. Savage, G. C. Tang, P. G. Sacks, R. R. Alfano, and S. P. Schantz, "Detecting retinoic acid-induced biochemical alterations in squamous cell carcinoma using intrinsic fluorescence spectroscopy," Laryngoscope, 104, pp. 278-282., 1994.

P. G. Cordeiro, R. E. Kirschner, Q. Y. Hu, J. J. Chiao, H. Savage, R. R. Alfano, L. A. Hoffman, and D. A. Hidalgo, "Ultraviolet excitation fluorescence spectroscopy: a noninvasive method for the measurement of redox changes in ischemic myocutaneous flaps," Plast Reconstr Surg, 96, pp. 673-680., 1995.

Y. Yang, G. C. Tang, M. Bessler, and R. R. Alfano, "Fluorescence spectroscopy as a photonic pathology method for detecting colon cancer," Lasers in the Life Sciences, 6,, pp. 259-276, 1995.

P. G. Sacks, H. E. Savage, J. Levine, V. R. Kolli, R. R. Alfano, and S. P. Schantz, "Native cellular fluorescence identifies terminal squamous differentiation of normal oral epithelial cells in culture: a potential chemoprevention biomarker," Cancer Lett, 104, pp. 171-181., 1996.

Y. Yang, A. Katz, E. J. Celmer, M. Zurawska-Szczepaniak, and R. R. Alfano, "Optical spectroscopy of benign and malignant breast tissues," Lasers in the Life Sciences, 7,, pp. 115-127, 1996.

S. P. Schantz, H. E. Savage, P. Sacks, and R. R. Alfano, "Native cellular fluorescence and its application to cancer prevention," Environ Health Perspect, 105 Suppl 4, pp. 941-944., 1997.

Y. Yang, E. J. Celmer, M. Zurawska-Szczepaniak, and R. R. Alfano, "Excitation spectrum of malignant and benign breast tissues: a potential optical biopsy approach," Lasers in the Life Sciences, 7,, pp. 249-265, 1997.

Y. Yang, A. Katz, E. J. Celmer, M. Zurawska-Szczepaniak, and R. R. Alfano, "Fundamental differences of excitation spectrum between malignant and benign breast tissues," Photochem Photobiol, 66, pp. 518-522., 1997.

J. C. Zhang, H. E. Savage, P. G. Sacks, T. Delohery, R. R. Alfano, A. Katz, and S. P. Schantz, "Innate cellular fluorescence reflects alterations in cellular proliferation," Lasers Surg Med, 20, pp. 319-331, 1997.

S. Ganesan, P. G. Sacks, Y. Yang, A. Katz, M. Al-Rawi, H. E. Savage, S. P. Schantz, and R. R. Alfano, "Native fluorescence spectroscopy of normal and malignant epithelial cells," Cancer Biochem Biophys, 16, pp. 365-373., 1998.

S. P. Schantz, V. Kolli, H. E. Savage, G. Yu, J. P. Shah, D. E. Harris, A. Katz, R. R. Alfano, and A. G. Huvos, "In vivo native cellular fluorescence and histological characteristics of head and neck cancer," Clin Cancer Res, 4, pp. 1177-1182, 1998.

Y. Guo, H. E. Savage, F. Liu, S. P. Schantz, P. P. Ho, and R. R. Alfano, "Subsurface tumor progression investigated by noninvasive optical second harmonic tomography," Proc Natl Acad Sci U S A, 96, pp. 10854-10856., 1999.

A. J. Papadopoulos, N. N. Zhadin, M. L. Steinberg, and R. R. Alfano, "Fluorescence spectroscopy of normal, SV40-transformed human keratinocytes, and carcinoma cells," Cancer Biochem Biophys, 17, pp. 13-23., 1999.

Y. Yang, E. J. Celmer, J. A. Koutcher, and R. R. Alfano, "UV reflectance spectroscopy probes DNA and protein changes in human breast tissues," J Clin Laser Med Surg, 19, pp. 35-39., 2001.

A. Katz, H. E. Savage, S. P. Schantz, S. A. McCormick, and R. R. Alfano, "Noninvasive Native Fluorescence Imaging of Head and Neck Tumors," Technology in Cancer Research and Treatment, 1, pp. 9-16, 2002.

Y. Yang, E. J. Celmer, J. A. Koutcher, and R. R. Alfano, "DNA and protein changes caused by disease in human breast tissues probed by the Kubelka-Munk spectral functional," Photochem Photobiol, 75, pp. 627-632., 2002.

R. R. Alfano and Y. Yang, "Stokes Shift Emission Spectroscopy of Human Tissue and Key Biomolecules," IEEE Journal of Selected Topics in Quantum Electronics, 9, pp. 148-153, 2003.

PRECEEDINGS

B. B. Das, W. L. Glassman, R. R. Alfano, J. Cleary, R.Prudente, E.Celmer, and S. Lubicz, "UV-fluorescence spectroscopic technique in the diagnosis of breast, ovarian, uterus, and cervix cancer," Proc. SPIE 1427, 368-373 (1991).

C. H. Liu, B. B. Das, W. L. S. Glassman, G. Tang, H. R. Zhu, D. L. Akins, S. Lubicz, J. Cleary, R.Prudente, E.Celmer, E.Caron, and R. R. Alfano, "NIR Raman and fluorescence spectroscopies diagnose cancer!," Proc. SPIE 1887, 188-194 (1993).

S. P. Schantz, H. E. Savage, P. G. Sacks, M. Silverberg, M. Lipkin, K. Yang, G. Tang, and R. R. Alfano, "Tissue autofluorescence spectroscopy: an intermediate endpoint for chemopreventive agents," Proc. SPIE 1887, 195-204 (1993).

G. C. Tang, H. E. Savage, M. Silverberg, P. G. Sacks, V. Reid, S. P. Schantz, and R. R. Alfano, "Native fluorescence spectroscopic detection of the effect of chemotherapeutic retinoids on a cancer model of the aerodigestive tract," in Optics for Protection of Man and Environment against Natural and Technological Disasters, G. von Bally and H. I. Bjielkhagen, Eds. Amsterdam: Elsevier, 1993, pp. 200-210.

Z. Z. Huang, W. S. Glassman, G. C. Tang, S. Lubicz, and R. R. Alfano, "Fluorescence diagnosis of gynecological cancerous and normal tissues," Proc. SPIE 2135, 42-45 (1994).

H. E. Savage, V. Kolli, J. Zhang, R. R. Alfano, P. G. Sacks, and S. P. Schantz, "Tissue autofluorescence spectroscopy: in vivo alterations may reflect cellular proliferation," Proc. SPIE 2135, 16-25 (1994).

Y. Yang, G. C. Tang, M. Bessler, and R. R. Alfano, "Optical Spectroscopy Methods to Detect Colon Cancer," Proc. SPIE 2135 (1994).

H. E. Savage, V. Kolli, S. Saha, J.-C. Zhang, M. Glasgold, P. G. Sacks, R. R. Alfano, and S. P. Schantz, "Development of in vitro models to elucidate mechanisms of intrinsic cellular and tissue fluorescence," Proc. SPIE 2387, 44-56 (1995).

H. E. Savage, V. Kolli, J. Ansley, R. Y. Chandawarkar, R. R. Alfano, and S. P. Schantz, "Innate tissue fluorescence of the oral mucosa of controls and head and neck cancer patients.," Proc. SPIE 2387, 2-14 (1995).

G. C. Tang, Y. L. Yang, Z. Z. Huang, F. Zhou, S. Cosloy, and R. R. Alfano, "Spectroscopic Properties of Tryptophan and Bacteria," Proc. SPIE 2387, 169-172 (1995).

R. A. Davis, H. E. Savage, P. G. Sacks, R. R. Alfano, and S. P. Schantz, "Influence of keratin on native cellular fluorescence of human skin," Proc. SPIE 2679, 216-226 (1996).

A. Katz, Y. Yang, E. J. Celmer, M. Zurawska-Szczepaniak, and R. R. Alfano, "Fourier Diagnostic Analysis of Fluorescence Spectra from Normal and Malignant Breast Tissues," Proc. SPIE 3, 136 (1996).

A. Katz, S.Ganesan, Y.-L. Yang, G. C. Tang, Y.Budansky, E. J. Celmer, H. E. Savage, S. P. Schantz, and R. R. Alfano, "Optical biopsy fiber-based fluorescence spectroscopy instrumentation," Proc. SPIE 2679, 118-123 (1996).

A. Katz and R. R. Alfano, "Optical Biopsy-Detecting Cancer with Light," Proc. SPIE 3, 132 (1996).

H. E. Savage, A. Katz, D. Harris, S. Ganesan, R. R. Alfano, and S. P. Schantz, "The hamster skin and DMBA-treated cheek pouch as in vivo models to study native cellular and tissue fluorescence," 4th International Conference on Head and Neck Cancer, Toronto 474, July 28 - August 1 1996.

G. C. Tang, E. J. Celmer, and R. R. Alfano, "Phosphorescence and fluorescence spectra from breast tissue," Proc. SPIE 2679, 102-105 (1996).

Y.-L. Yang, A. Katz, E. J. Celmer, M. Zurawska-Szczepaniak, and R. R. Alfano, "Optical spectroscopy of benign and malignant breast tissues," Proc. SPIE 2679, 51-54 (1996).

N. Zhadin, Y.-L. Yang, S.Ganesan, N. Ockman, and R. R. Alfano, "Enhancement of the fluorescence cancer diagnostic method of tissues using diffuse reflectance and the analysis of oxygenation state," Proc. SPIE 2679, 142-148 (1996).

D. Parmeswaran, S. Ganesan, R. Nalini, P. Aruna, V. Veeraganesh, and R. R. Alfano, "Native cellular fluorescence characteristics of normal and malignant epithelial cells from human larynx," Proc. SPIE 2979, 759-764 (1997).

G. C. Tang, A. Katz, Y. Budansky, R. Krumm, and R. R. Alfano, "Fluorescence Optic Fiber Stereotactic Needle Ratiometer for Breast Tumor Diagnosis," Proc. SPIE (1997).

N. N. Zhadin, Y.-L. Yang, N. Ockman, and R. R. Alfano, "Biochemical distinctions between normal and cancerous human breast tissues obtained from fluorescence spectroscopy," Proc. SPIE 2979, 585-588 (1997).

A. Katz, H. E. Savage, F.-A. Zeng, J. Rome, G. C. Tang, D.Harris, J. Koutcher, S. P. Schantz, and R. R. Alfano, "Fluorescence ratio mapping system for tissue diagnosis," Proc. SPIE 3250, 64-67 (1998).

Y. Yang, A. Katz, E. J. Celmer, J. A. Koutcher, and R. R. Alfano, "Excitation Spectroscopy of Proteins in Malignant and Benign Tissues," Proc. SPIE 22 (1998).

Y. Yang, E. J. Celmer, J. A. Koutcher, and R. R. ALfano, "Excitation Spectroscopy Reveals Changes of Proteins and the Degree of Invasion in Malignant Tissues," Proc. SPIE 3597 (1999).

A. Katz and R. R. Alfano, "Fluorescence-based instrumentation for cancer detection," Proc. SPIE 3913 (2000).

A. Katz, H. E. Savage, Y. Yang, F. Zeng, J. Rome, S. A. McCormick, R. S. Cocker, Y. Yu, and R. R. Alfano, "Ultraviolet and blue 2-D fluorescence mapping of gynecological tissues," Proc. SPIE 3917 (2000).

A. Katz, H. E. Savage, F. Zeng, J. Rome, S. A. McCormick, R. S. Cocker, S. P. Schantz, and R. R. Alfano, "Ultraviolet 2-D fluorescence mapping system for the imaging of head and neck tumors," Proc. SPIE 3917 (2000).

R. R. Alfano and Y. Yang, "Stokes shift emission spectroscopy of human tissue and key biomolecules," Proc. SPIE 5326, To be published (2004).